Last month we began our report on findings in OPPERA’s Act Two," the second series of analyses of data from the Orofacial Pain Prospective Evaluation and Risk Assessment (OPPERA) study, which enrolled healthy volunteers at four campus sites in Chapel Hill, NC; Baltimore; MD; Buffalo, NY; and Gainesville, FL. Follow-up questionnaires were available from 2,737 enrollees, and clinical examinations in the course of the study documented that 260 of these people developed first-onset TMD.